Long-haul flight: Is it reasonable to ask for a same-row, same-type seat swap so we can sit together?

My husband and I are flying Delta on a long-haul flight from JFK to Athens for our honeymoon in May on an Airbus A330-900neo, which has a 2-4-2 configuration in both Comfort+ and Main Cabin. We’re considering paying to upgrade to Comfort+, but all the paired seats are already taken - except for row 36, where one side has an aisle seat available and the other side has a window seat available. Both sides with the open seat are in the two seat configuration, not the four.

I generally don’t like asking people to switch seats, but I’m wondering: would it be considered out of line to politely ask one of our neighbors to swap seats if it’s for the same cabin, same seat type (aisle for aisle or window for window - two seat row, not four seat), and in the same row? Given that there aren’t any two seats together available, I’m trying to figure out if that would be a reasonable request or if we should just accept sitting apart.

Also goes without saying, I'd throw out a disclaimer feel free to say no, no pressure, and mean it.